Procion yellow M-4RS binding to neuronal membranes.

نویسندگان

  • M T Flanagan
  • T R Hesketh
  • S H Chung
چکیده

Procion Yellow M-4R8, an intracellular neuronal marker, has been shown to bind covalently to the subcellular organelles of rat brain under physiologic conditions. Binding to purified proteins, nucleic acids and lipids also occurs under such conditions, the probable site of attachment being the primary amino group. Lipid membranes were highly impermeable to this dye. The fluorescence intensity of Procion Yellow M-4R8 was shown to be viscosity-dependent. These results are consistent with the behavior of the dye when it is used for mapping neurons.

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عنوان ژورنال:
  • The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

دوره 22 10  شماره 

صفحات  -

تاریخ انتشار 1974